Applying response surface methodology to optimize nimesulide permeation from topical formulation
نویسندگان
چکیده
منابع مشابه
Applying response surface methodology to optimize nimesulide permeation from topical formulation.
Nimesulide is a non-steroidal anti-inflammatory drug that acts through selective inhibition of COX-2 enzyme. Poor bioavailability of this drug may leads to local toxicity at the site of aggregation and hinders reaching desired therapeutic effects. This study aimed at formulating and optimizing topically applied lotions of nimesulide using an experimental design approach, namely response surface...
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ژورنال
عنوان ژورنال: Pharmaceutical Development and Technology
سال: 2012
ISSN: 1083-7450,1097-9867
DOI: 10.3109/10837450.2012.723721